Vegan-specific signature implies healthier metabolic profile: findings from diet-related multi-omics observational study based on different European populations
Reports hub
1 Reports hub
All reports use an initialization file and custom R functions file in this folder. Initiation file includes basic data preprocessing and wrangling, loading packages, etc. The custom R functions contain definition and description of each custom function used for this project in Roxygen format.
A report 478_code04_methods describes the statistical methodology in details.
Other reports provide a step-by-step analysis of each dataset (microbiome, metabolome, lipidome), detailing linear models that assess the effects of diet
, country
, and their interaction (diet:country
) on individual features. They also include elastic net regression models used to predict vegan status based on omics features and an external validation of both the linear models and predictive regressions using an independent cohort.
- 478_code01_metabolom shows analysis of metabolom
- 478_code02_lipidom shows analysis of lipidom
- 478_code03_microbiome shows analysis of microbiome (mimimal prevalence set to 30%; primary analysis)
- 478_code03_microbiome_prev10 shows analysis of microbiome, but with the threshold for the prevalence of taxon set to only 10% (secondary analysis)
- 478_code03_microbiome_prev50 shows analysis of microbiome, but with the threshold for the prevalence of taxon set to stricter 50% (secondary analysis)
- 478_code05_pathways_analysis shows analysis of pathways